|
|
acyl-CoA + NAD+ <=> trans-2-enoyl-CoA + NADH + H+
|
1.3.1.44
trans-2-enoyl-CoA reductase (NAD+)
|
–
|
| |
BRENDA:
BR36826;
BS370148
KEGG:
R00384
|
|
|
|
2-oxoisovalerate + acetyl-CoA + H2O <=> H+ + (2S)-2-isopropylmalate + CoA
|
2.3.3.13
2-isopropylmalate synthase
2.3.3.17
methylthioalkylmalate synthase
|
–
–
|
| |
BRENDA:
BR47381;
BS353415;
BS375022;
BS438748
KEGG:
R01213
MetaCyc:
2-ISOPROPYLMALATESYN-RXN
SABIO-RK:
545
|
|
|
|
2-isocaprenoyl-CoA + (R)-2-hydroxyisocaproate <=> (E)-4-methyl-2-pentenoate + D-2-hydroxyisocaproyl-CoA
|
2.8.3.B1
|
–
|
| |
BRENDA:
BR51452
|
|
|
|
3-methylcrotonoyl-CoA + HCO3- + ATP <=> trans-3-methylglutaconyl-CoA + ADP + phosphate + H+
|
6.4.1.4
methylcrotonoyl-CoA carboxylase
6.4.1.5
geranoyl-CoA carboxylase
|
–
–
|
| |
BRENDA:
BR156
KEGG:
R04138
MetaCyc:
METHYLCROTONYL-COA-CARBOXYLASE-RXN
SABIO-RK:
3859
|
|
|
|
D-2-hydroxyisocaproyl-CoA <=> 2-isocaprenoyl-CoA + H2O
|
4.2.1.157
(R)-2-hydroxyisocaproyl-CoA dehydratase
|
–
|
| |
BRENDA:
BR51460
KEGG:
R11076
MetaCyc:
RXN-16247
|
|
|
|
4-methyl-2-oxopentanoate + CoA + oxidized_ferredoxin <=> isovaleryl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+
|
1.2.7.7
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
1.2.7.8
indolepyruvate ferredoxin oxidoreductase
|
–
–
|
| |
BRENDA:
BS359415
KEGG:
R08566
MetaCyc:
RXN-19534
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
| |
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
(2R,3S)-3-isopropylmalate + NAD+ <=> (2S)-2-isopropyl-3-oxosuccinate + NADH + H+
|
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
|
| |
BRENDA:
BR47597;
BS373119
KEGG:
R04426
MetaCyc:
3-ISOPROPYLMALDEHYDROG-RXN
|
|
|
|
L-leucine <=> (3R)-beta-leucine
|
5.4.3.7
leucine 2,3-aminomutase
|
–
|
| |
BRENDA:
BR31;
BS1198
KEGG:
R01091
MetaCyc:
LEUCINE-23-AMINOMUTASE-RXN
|
|
|
|
isovaleryl-CoA + FAD <=> 3-methylcrotonoyl-CoA + FADH2
|
1.3.8.4
isovaleryl-CoA dehydrogenase
1.3.8.7
medium-chain acyl-CoA dehydrogenase
|
–
–
|
| |
BRENDA:
BS424839
KEGG:
R04095
SABIO-RK:
3822
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> H2O + trans-3-methylglutaconyl-CoA
|
4.2.1.18
methylglutaconyl-CoA hydratase
|
–
|
| |
BRENDA:
BR3388
KEGG:
R02085
MetaCyc:
METHYLGLUTACONYL-COA-HYDRATASE-RXN
SABIO-RK:
2095
|
|
|
|
2-isopropylmaleate + H2O <=> (2S)-2-isopropylmalate
|
4.2.1.33
3-isopropylmalate dehydratase
|
–
|
| |
BRENDA:
BR413;
BR49521;
BS1964
KEGG:
R03968;
R04001
MetaCyc:
3-ISOPROPYLMALISOM-RXN;
RXN-8991
SABIO-RK:
3704;
3736
|
|
|
|
(S)-3-hydroxy-3-methylglutaryl-CoA <=> acetoacetate + acetyl-CoA
|
4.1.3.4
hydroxymethylglutaryl-CoA lyase
|
–
|
| |
BRENDA:
BR395;
BS416230
KEGG:
R01360
MetaCyc:
HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN
SABIO-RK:
1564
|
|
|
|
L-leucine + 2-oxoglutarate <=> L-glutamate + 4-methyl-2-oxopentanoate
|
2.6.1.1
aspartate transaminase
2.6.1.2
alanine transaminase
2.6.1.39
2-aminoadipate transaminase
2.6.1.42
branched-chain-amino-acid transaminase
2.6.1.57
aromatic-amino-acid transaminase
2.6.1.6
leucine transaminase
2.6.1.67
2-aminohexanoate transaminase
2.6.1.9
histidinol-phosphate transaminase
|
–
–
–
–
–
–
–
–
|
| |
BRENDA:
BR47691
KEGG:
R01090
MetaCyc:
BRANCHED-CHAINAMINOTRANSFERLEU-RXN
SABIO-RK:
1352
|
|
|
|
4-methylpentanoyl-CoA + (R)-2-hydroxyisocaproate <=> 4-methylpentanoate + D-2-hydroxyisocaproyl-CoA
|
2.8.3.24
(R)-2-hydroxy-4-methylpentanoate CoA-transferase
|
–
|
| |
BRENDA:
BR51714
KEGG:
R11462
MetaCyc:
RXN-16246
|
|
|
|
H+ + (2S)-2-isopropyl-3-oxosuccinate <=> 4-methyl-2-oxopentanoate + CO2
|
0.0.0.0
1.1.1.85
3-isopropylmalate dehydrogenase
|
–
–
|
| |
BRENDA:
BR52894
KEGG:
R01652
MetaCyc:
RXN-7800
|
|
|
|
ATP + L-leucine + tRNALeu <=> AMP + diphosphate + L-leucyl-tRNALeu
|
6.1.1.4
leucine---tRNA ligase
|
–
|
| |
BRENDA:
BR55
KEGG:
R03657
SABIO-RK:
412
|
|
|
|
3-methyl-1-butanol + NAD+ <=> Isovaleraldehyde + NADH + H+
|
1.1.1.1
alcohol dehydrogenase
1.1.1.2
alcohol dehydrogenase (NADP+)
1.1.1.265
3-methylbutanal reductase
|
–
–
–
|
| |
BRENDA:
BR26045-a
KEGG:
R05685
MetaCyc:
1.1.1.265-RXN_WOP;
RXN-7693
SABIO-RK:
5281
|
|
